Clinical study of Masquelet technique in the treatment of osteomyelitis and bone defect

Bikash Neupane, Zhao Meng, Xu Sheng Kang, Prabha Paudel, Sagar Panthi, Zhao Xing, Zhang Jin Song


Background: The induced membrane technique, introduced by Masquelet in 1986 called Masquelet technique is universally preferred methods of treatment in bone defect either of any cause. Consists of two principle steps: first radical debridement and filling defect with polymethylmethacrylate (PMMA) spacer, this allows the formation of induction membrane. Secondly bone cement is removed and defect is filled with bone graft and stabilized with definitive fixation.

Methods: This prospective observational study was carried out in the department of orthopedic surgery, Taihe Hospital affiliated to Hubei University of Medicine, Shiyan Hubei China from July 2018 to November 2019.

Results: Total 32 patients observed and recorded for the analysis. The mean age 38.28±11.211 years. 20 (62.5%) male and 12 (37.5%) female, 13 (40.6%) had right, and 19 (59.4%) had left side injury. Tibia has the highest involvement 16 (50%), femur 10 (31.3%), calcaneus 3 (9.4%) radius, cuboid and ulna 1 (3.1%) each. For cause of defect osteomyelitis is found to have highest frequency of 11 (34.4%). The size of defect ranges from 3 to 20 cm with mean defect (6.91±4.489 cm). Duration of bone cement ranges from 4-20 weeks with mean of 8.75±3.379 weeks. The union time ranges from 4-14 months. With mean of 8.31±2.17 months. 18 (56.3%) have excellent results, 13 (40.6%) have good results, and 1 patient (3.1%) have satisfactory results.

Conclusions: This study concludes that Masquelet technique as being the more appropriate, reliable and is a noble technique in the reconstruction of bone defect either of any cause with good functional result.


Masquelet technique, Bone defects, Induced membrane, Reconstruction

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